期刊简介
本杂志是由中华人民共和国卫生主管，同济医科大学附属协和医院主办，国内外公开发行的学术性期刊，1996年被评为全国优秀期刊。辟有专家论坛、临床研究、实验研究、技术与方法、研究报告、综述、进修苑、学术争鸣、经验介绍及病例报告等多个栏目。
往期目录
-
1998
-
1999
-
2000
-
2001
-
2002
-
2003
-
2004
-
2005
-
2006
-
2007
-
2008
-
2009
-
2010
-
2011
-
2012
-
2013
-
2014
-
2015
-
2016
-
2017
-
2018
首页>临床耳鼻咽喉头颈外科杂志
- 杂志名称：临床耳鼻咽喉头颈外科杂志
- 主管单位：中华人民共和国教育部
- 主办单位：华中科技大学同济医学院附属协和医院
- 国际刊号：1001-1781
- 国内刊号：42-1764/R
- 出版周期：半月刊
期刊荣誉：第二届国家期刊奖提名奖期刊收录：万方收录(中), 维普收录(中), 国家图书馆馆藏, 知网收录(中), 上海图书馆馆藏, CA 化学文摘(美), 文摘与引文数据库, 北大核心期刊(中国人文社会科学核心期刊), 统计源核心期刊(中国科技论文核心期刊), JST 日本科学技术振兴机构数据库(日)
IL-12细胞因子家族在变应性鼻炎中的研究进展
尹雪；王建星；徐鸥；董金辉；刘春苗
关键词：IL-12, 鼻炎, 变应性, 细胞因子类
摘要：Summary:As the IL-12 family plays an important role in immune regulation,it arouses the attention of the researchers increasingly.There are mainly four members in the IL-12 family,including IL-12,IL-23,IL-27 and IL-35 at present.The family members share many similar structures,but they have their own distinctive biological characteristics and play different roles to balance the functional effects of their own family.IL-12 and IL-23 are positive regulators and mainly play pro-inflammatory effect while IL-27 and IL-35 are negative regulators and mainly play anti-inflammatory effect.Thus,IL-12 family plays an important role in the regulation of the immune response and this function may be better than other cytokine family.IL-12 family has an important regulatory effect on multiple T cell subsets and also has an impact on their differentiation and function.So,we postulate that the IL-12 family may have an intense relationship with the generation and development of the allergic rhinitis.This article will mainly talk about the unique structure and role of the IL-12 cytokine family and discuss its immune regulation effect in the allergic rhinitis.
友情链接