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本杂志是由中华人民共和国卫生主管，同济医科大学附属协和医院主办，国内外公开发行的学术性期刊，1996年被评为全国优秀期刊。辟有专家论坛、临床研究、实验研究、技术与方法、研究报告、综述、进修苑、学术争鸣、经验介绍及病例报告等多个栏目。
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首页>临床耳鼻咽喉头颈外科杂志
- 杂志名称：临床耳鼻咽喉头颈外科杂志
- 主管单位：中华人民共和国教育部
- 主办单位：华中科技大学同济医学院附属协和医院
- 国际刊号：1001-1781
- 国内刊号：42-1764/R
- 出版周期：半月刊
期刊荣誉：第二届国家期刊奖提名奖期刊收录：万方收录(中), 维普收录(中), 国家图书馆馆藏, 知网收录(中), 上海图书馆馆藏, CA 化学文摘(美), 文摘与引文数据库, 北大核心期刊(中国人文社会科学核心期刊), 统计源核心期刊(中国科技论文核心期刊), JST 日本科学技术振兴机构数据库(日)
miRNA在喉癌中作用机制的研究进展
彭永华；杨文飞；卢绍伟；兰贤斌
关键词：喉癌, 微小RNA, 生物行为, 作用机制
摘要：MiRNA(miR) is a non-coding small RNA of 18 to 24 nucleotides in length.By pairing with 3'UTR of its target mRNA molecule,miRNA regulateS the target mRNA molecule in the translation level or direct ly lead to its degradation.Each miRNA may target several to several hundred mRNAs,of which 30％ of the mR-NA is regulated by miRNAs.Some studies have shown that miRNA expression disorders play an important role in the development and progression of various tumors and may be the ideal target for tumor therapy.It has been shown that abnormal expression of RNA(miRNA) plays an important role in the occurrence and development of laryngeal cancer.Wang Ping found 47 kinds of miRNA expression abnormalities in laryngeal cancer tissue with microarray chip detection,that of which high expression were 23 kinds and low expression were 24 kinds.MiRNAs that are abnormally expressed in laryngeal squamous cell carcinoma are expected to be a new marker for early diagnosis of laryngeal cancer.In this review,we summarized the progress in recent three years on the association of miRNA and the biological behaviors of laryngeal cancer.
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